This low dose will also give you time to see how your body reacts to dnp. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Incompatible with heavy metals and their compounds. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. Download tunnelguru application for your desktop and mobile device. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. Get a printable copy pdf file of the complete article 2. Pdf two deaths attributed to the use of 2,4dinitrophenol. Safety data sheet northwest missouri state university. Effects of 2,4dinitrophenol and other metabolic inhibitors. A phenolate anion obtained from 2, 4 dinitrophenol. Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc.
This is a chemical that was once used in the early 20th century to ignite dynamite and cast a yellow dye on wood and other handcrafts. Medical knowledge, especially in toxicology, is built on experimentation and the preciously won experience over time treating the ingestions and poisonings of our patients. This material does not contain any class 2 ozone depletors. Dnp by moving protons across the mitochondrial membrane breaks the process of oxidative phosphorylation, whereby there is an active waste of energy, but without the synthesis of adenosine triphosphate molecules. This material does not contain any class 1 ozone depletors. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5.
Ignoring these hard won lessons, and having additional patients repeat the suffering is a most pitiful waste. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. Fast reliable simple online tunnel to protect your privacy. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system.
New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. Removal of 2, 4dinitrophenol by ferrate by gianna griffith cooley b. Dnp ist ein gelber kristalliner feststoff mit phenolartigem geruch. What is 2,4dnph and why are schools carrying out controlled. Later on in the 19 th century chemists invented tnt 2, 4,6trinitrotoluene and 2, 4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings.
Information from its description page there is shown below. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. A few years later demographical statistics showed that employees who worked with dnp everyday tended to lose weight, often rapidly. This has been the case with 2, 4 dinitrophenol dnp, which despite abundant evidence of its. Buy 2 4 dinitrophenol book online at low prices in. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. Anyway, i learned about a chemical called 2, 4 dinitrophenol or dnp, which is what they call it in bodybuilding circles. Links to pubmed are also available for selected references. Loyola univeristy new orleans, 2002 a thesis submitted in partial fulfillment of the requirements for the degree of master of environmental engineering in the department of civil and environmental engineering in the college of engineering and computer science. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. A weight loss agent with significant acute toxicity and risk of death. Structure, properties, spectra, suppliers and links for.
It is a yellow, crystalline solid that has a sweet, musty odor. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Surf anonymously, securely, increase internet speed. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. This page is regularly updated, to include the most recently available clinical trial evidence. Everything about dnp 2,4dinitrophenol pharma forums. Full text is available as a scanned copy of the original print version. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2, 4 dinitrophenol 2, 4 dnp. Also incompatible with strong oxidizing agents, strong bases and reducing agents. It has a role as a bacterial xenobiotic metabolite. Based on these effects, the established maximum acceptable toxicant concentration for fathead minnows in lake superior water lies between 1,970 and 3,110 ugl for 2,4dimethylphenol. The results from these studies, however, have shown a multiplicity of effects that suggest a more complicated interaction with the mtx transport system than adenosine 5. Buy 2 4 dinitrophenol book online at best prices in india on.
Despite not being licensed for human consumption, the internet has triggered renewed, widespread interest and availability of 2,4dinitrophenol dnp. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Strictly speaking, the former is more correct, though the latter is commonly used to refer to it too. Growth of 28 day old fish was the most sensitive indicator of stress during exposures to 2,4dimethylphenol. Articles of 2, 4 dinitrophenol are included as well. Chronic longterm oral exposure to 2,4dinitrophenol in humans has resulted in the formation of cataracts and skin lesions, weight loss, and has caused effects. Selective adsorption and efficient photodegradation of 2, 4 dinitrophenol in aqueous solution, journal of hazardous materials, vol. Youve probably seen 2,4dinitrophenylhydrazine referred to alternately as 2,4dnph or 2,4dnp. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture.
Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. It is a yellow, crystalline solid that has a sweet, musty. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b. Show this safety data sheet to the doctor in attendance.
O 2,4dinitrofenol e rapidamente adsorvido atraves do trato gastrointestinal, bem com pela pele e pulmoes. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. Like tnt, it was found to be toxic to the munition workers handling it. For additional information on the health effects of this chemical, interested parties are referred to the. Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own.